About the PI
Diane C. Lim, MD, MTR
Associate Professor, Medicine
Education & Training
1990 Pacific Union College, BS, Biology, Minor in Music 1995 Loma Linda University, School of Medicine, MD 1995-1998 Loma Linda University, School of Medicine, Internal Medicine Residency 1990-2001 Loma Linda University, School of Medicine, Pulmonary and Critical Care Fellowship 2007-2010 University of Pennsylvania, School of Medicine, Sleep Fellowship 2007-2012 University of Pennsylvania, School of Medicine, Post-Doc in Sleep and Neurobiology 2007-2012 University of Pennsylvania, School of Medicine, Masters in Translational ResearchPositions
2001-2003 Assistant Professor, Department of Medicine, Division of Pulmonary and Critical Care, LLUMC
Information Technology Committee
IRB
2003-2007 Assistant Professor, Department of Medicine, Division of Pulmonary and Critical Care, Drexel University
Associate Program Director of Internal Medicine Residency
Educational Committees, Medical Students, Internal Medicine Residents/Fellows
Neuro ICU Director, Hahnemann University Hospital
Medical ICU Director, Medical College of Pennsylvania
Founder, Drexel Collaborative Research Forum - bringing together engineers, physicians and scientists to discuss how we can integrate our strengths collectively
2010-2015 Instructor, Department of Medicine, University of Pennsylvania
2015-2021 Staff Physician, Department of Medicine, Philadelphia VA Medical Center
2015-2021 Assistant Professor, Department of Medicine, University of Pennsylvania
2021-present Associate Professor (pending), Department of Medicine, University of Miami
2021-present Staff Physician, Department of Medicine, Miami VA Medical Center
Honors
2000 Alpha Omega Alpha Honor Medical Society (AOA)
2002 Attending of the Year Award, given by Internal Medicine Residents, LLUMC
2004 Golden Apple, given by Drexel University Medical Students
2006 Teaching Award, given by Family Practice Residents, Drexel University
2019 Employee Engagement Award, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA
Current/Past Funding
1 I01 BX004872-01 (Lim) 01/01/20-12/31/23
BLR&D Merit Review Award, Veterans Affairs Healthcare Network
Title: Effects of cyclical intermittent hypoxia on Lung Cancer Progression
3I01BX004872-03 (Lim, Mentee: Knott) 07/01/2022-06/30/2023
BLR&D VA DEI Supplement Application
Title: Effects of cyclical intermittent hypoxia on Lung Cancer Progression
Dr. Knott will look at the role of immunosenescence in lung cancer progression in aged mice.
1 R01 HL 142981-01A1 (PI: Aalim Weljie, Co-PI: Lim) 07/01/20-06/30/24
NIH/NHLBI
Title: Metabolomics of Obstructive Sleep Apnea
Intra-Programmatic Cancer Grant (PI: Lim, Co-PI: Wangpaichitr & Holt) 09/01/21-05/30/22
Sylvester Comprehensive Cancer Center, University of Miami Health System
Title: A translational approach to understanding the role of the Immunometabolic Tryptophan Switch when treating lung cancer
1 R56 HL148430-01 (PI: Jinyoung Kim, Co-I: Lim) 9/20/19-8/31/20
NIH/NHLBI
Title: Personalizing obstructive sleep apnea management: associating symptom subtype to objective sleep traits and physiological biomarkers
Selected Publications
Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer
Chunjing Wu, Sydney A. Spector, George Theodoropoulos, Dan JM Nguyen, Emily Y. Kim, Ashley Garcia, Niramol Savaraj, Diane C. Lim, Ankita Paul, Lynn G. Feun, Michael Bickerdike, Medhi Wangpaichitr
Cancer & Metabolism. 11, 7 (2023)
Predicting brain age based on sleep EEG and DenseNet
Soonhyun Yook, Yizhan Miao, Claire Park, Hea Ree Park, Jinyoung Kim, Diane C Lim, Eun Yeon Joo, Hosung Kim
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:245-248
Defining Extreme Phenotypes of OSA Across International Sleep Centers
Fabiola G Rizzatti, Diego R Mazzotti, Jesse Mindel, Greg Maislin, Brendan T Keenan, Lia Bittencourt, Ning-Hung Chen, Peter A Cistulli, Nigel McArdle, Frances M Pack, Bhajan Singh, Kate Sutherland, Bryndis Benediktsdottir, Ingo Fietze, Thorarinn Gislason, Diane C Lim, Thomas Penzel, Bernd Sanner, Fang Han, Qing Yun Li, Richard Schwab, Sergio Tufik, Allan I Pack, Ulysses J Magalang
CHEST 2020 Sep;158(3):1187-1197
Reinventing polysomnography in the age of precision medicine
Diane C. Lim, Diego R. Mazzotti, Kate Sutherland, Jesse W Mindel, Jinyoung Kim, Peter A. Cistulli,Ulysses J. Magalang, Allan I. Pack, Phillip de Chazal, Thomas Penzel, SAGIC Investigators
Sleep Medicine Reviews 2020 Aug;52:101313
Brendan T. Keenan, Raymond J. Galante, Jie Lian, Petr Simecek, Daniel M. Gatti, Lin Zhang, Diane C. Lim, Karen L. Svenson, Gary A. Churchill, Allan I. Pack
Sleep 2020 May 12;43(5):zsz278
Blood pressure monitoring in sleep: time to wake up
Younghoon Kwon, Patrick L Stafford, Diane C Lim, Sungha Park, Sung-Hoon Kim, Richard B Berry, David A Calhoun
Blood Press Monit 2020 Apr;25(2):61-68
Age attenuates the transcriptional changes that occur with sleep in the medial prefrontal cortex.
Xiaofeng Guo, Brendan T. Keenan, Dimitra Sarantopoulou, Diane C. Lim, Jie Lian, Gregory R. Grant, Allan I. Pack
Aging Cell 2019 Dec 18(6):e13021
Xiaofeng Guo, Yan Liu, Jessica Kim, Emily Y. Kim, Edison Q. Kim, Alexandria Jansen, Katherine Li, May Chan, Brendan T. Keenan, Jose Conejo-Garcia, Diane C. Lim
PLOS ONE 2019 Feb 27;14(2):e0212930
Symptom Subtypes of Obstructive Sleep Apnea Predict Incidence of Cardiovascular Outcomes.
Diego R. Mazzotti, Brendan T. Keenan, Diane C. Lim, Daniel J. Gottlieb, Jinyoung Kim, Allan I. Pack
American Journal of Respiratory and Critical Care Medicine 2019 Aug 15;200(4):493-506
Home sleep apnea testing: comparison of manual and automated scoring across international sleep centers
Ulysses J Magalang, Jennica N Johns, Katherine A Wood, Jesse W Mindel, Diane C Lim, Lia R Bittencourt, Ning-Hung Chen, Peter A Cistulli, Thorarinn Gíslason, Erna S Arnardottir, Thomas Penzel, Sergio Tufik, Allan I Pack
Sleep Breath 2019 Mar;23(1):25-31
Symptom-Based Subgroups of Koreans With Obstructive Sleep Apnea
Jinyoung Kim, Brendan T. Keenan, Diane C. Lim, Seung Ku Lee, Allan I. Pack, Chol Shin
Journal of Clinical Sleep Medicine 2018 Mar 15;14(3):437-443
P4 medicine approach to obstructive sleep apnoea
Diane C. Lim, Kate Sutherland, Peter A. Cistulli, Allan I. Pack
Respirology 2017 Jul;22(5):849-860
Obstructive Sleep Apnea: Update and Future
Diane C. Lim, Allan I. Pack
Annual Review of Medicine 2017 Jan 14;68:99-112
Diane C. Lim, Daniel C. Brady, Rajath E. Soans, Emily Y. Kim, Laise Valverde, Brendan T. Keenan, Xiafeng Guo, Woo Young Kim, Min Jeong Park, Raymond Galante, James A. Shackleford, Allan I, Pack
Journal of Applied Physiology 2016 Jul 1;121(1):78-88
Developing Biomarker Arrays Predicting Sleep and Circadian-Coupled Risks to Health
Janet Mullington, Sabra M. Abbott, Judith E. Carroll, Christopher J. Davis, Derk-Jan Dijk, David F. Dinges, Philip R. Gehrman, Geoffrey S. Ginsburg, David Gozal, Monika Haack, Diane C. Lim, Madalina Macrea, Allan I. Pack, David T. Plante, Jennifer A. Teske, Phyllis C. Zee
Sleep 2016 Apr 1;39(4):727-36
Automated Protein Localization of Blood Brain Barrier Vasculature in Brightfield IHC Images
Rajath E. Soans, Diane C. Lim, Brendan T. Keenan, Allan I. Pack, James Shackleford
PLOS ONE 2016 Feb 1;11(20):e0148411
Diane C. Lim, Daniel C. Brady, Pengse Po, Li-Pang Chuang, Laise Marcondes, Emily Y. Kim, Brendan T. Keenan, Xiaofeng Guo, Greg Maislin, Raymond J. Galante, Allan I. Pack
Journal of Applied Physiology 2015 Mar 1;118(5):544-57
Erna S. Arnardottir, Diane C. Lim, Brendan T. Keenan, Greg Maislin, Bryndis Benediktsdottir, Sigurdur Juliusson, Allan I. Pack, Thorarinn Gislason
Journal of Sleep Research 2015 Apr 1;24(2):148-59
Obstructive sleep apnea and cognitive impairment: addressing the blood-brain barrier.
Diane C. Lim, Allan I. Pack
Sleep Medicine Reviews 2014 Feb 1;18(1):35-48